Please use this identifier to cite or link to this item: http://hdl.handle.net/10397/20940
DC FieldValueLanguage
dc.contributorDepartment of Applied Biology and Chemical Technology-
dc.creatorLuo, M-
dc.creatorLu, Z-
dc.creatorSun, H-
dc.creatorYuan, K-
dc.creatorZhang, Q-
dc.creatorMeng, S-
dc.creatorWang, F-
dc.creatorGuo, H-
dc.creatorJu, X-
dc.creatorLiu, Y-
dc.creatorYe, T-
dc.creatorLu, Z-
dc.creatorZhai, Z-
dc.date.accessioned2015-06-23T09:08:03Z-
dc.date.available2015-06-23T09:08:03Z-
dc.identifier.urihttp://hdl.handle.net/10397/20940-
dc.language.isoenen_US
dc.publisherInst Biochemistry & Cell Biologyen_US
dc.subjectApoptosisen_US
dc.subjectCaspase-3en_US
dc.subjectNuclear entryen_US
dc.subjectNuclear export signalen_US
dc.titleNuclear entry of active caspase-3 is facilitated by its p3-recognition-based specific cleavage activityen_US
dc.typeJournal/Magazine Articleen_US
dc.identifier.spage211-
dc.identifier.epage222-
dc.identifier.volume20-
dc.identifier.issue2-
dc.identifier.doi10.1038/cr.2010.9-
dcterms.abstractAs a critical apoptosis executioner, caspase-3 becomes activated and then enters into the nucleus to exert its function. However, the molecular mechanism of this nuclear entry of active caspase-3 is still unknown. In this study, we revealed that caspase-3 harbors a crm-1-independent nuclear export signal (NES) in its small subunit. Using reverse-caspase-3 as the study model, we found that the function of the NES in caspase-3 was not disturbed by the conformational changes during induced caspase-3 activation. Mutations disrupting the cleavage activity or p3-recognition site resulted in a defect in the nuclear entry of active caspase-3. We provide evidence that the p3-mediated specific cleavage activity of active caspase-3 abrogated the function of the NES. In conclusion, our results demonstrate that during caspase-3 activation, NES is constitutively present. p3-mediated specific cleavage activity abrogates the NES function in caspase-3, thus facilitating the nuclear entry of active caspase-3.-
dcterms.bibliographicCitationCell research, 2010, v. 20, no. 2, p. 211-222-
dcterms.isPartOfCell Research-
dcterms.issued2010-
dc.identifier.isiWOS:000275816100012-
dc.identifier.scopus2-s2.0-76449100488-
dc.identifier.pmid20101263-
dc.identifier.rosgroupidr49952-
dc.description.ros2009-2010 > Academic research: refereed > Publication in refereed journal-
Appears in Collections:Journal/Magazine Article
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