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Title: Effects of aqueous extract from Salvia miltiorrhiza Bunge on serum lipid level and liver in ovariectomized rats
Authors: Li, CM
Yang, RF
Gu, QL
Wang, B
Wu, JH
Fan, XD
Chan, SW
Qiu, TQ
Wong, MS 
Keywords: Aqueous extract
Ovariectomized rat
Salvia miltiorrhiza Bunge
Serum lipid
Issue Date: 2012
Publisher: 華南理工大學學報編輯委員會
Source: 华南理工大学学报. 自然科学版 (Journal of South China University of Technology. Natural science), 2012, v. 40, no. 12, p. 151-156 How to cite?
Journal: 华南理工大学学报. 自然科学版 (Journal of South China University of Technology. Natural science) 
Abstract: In order to evaluate the estrogenic effect of Salvia miltiorrhiza Bunge (SM), 32 six-month-old female SD rats were randomly divided into 4 groups, namely, sham-operated rats + vehicle (marked as Sham), ovariectomized rats + vehicle (marked as OVX), ovariectomized rats + 17 β-estradiol (1 mg·kg-1·d-1, p.o., marked as E2), ovariectomized rats + SM (600 mg·kg-1·d-1, p.o., marked as SM). After the treatment for 12 weeks, the body weight gain, uterus weight index, serum lipid level, serum transaminase activity and oxidant/antioxidant level were detected, and a histological examination of the liver was carried out. The results show that the treatment with aqueous extract for 12 weeks helps to reduce the body weight gain, stimulate the growth of the atrophic uterus, improve the serum lipid level, decrease the ALT and AST levels in serum and suppress the lipid accumulation in the liver of ovariectomized rats. All these above-mentioned protective effects of SM extract probably relate to the inhibition of oxidant (Methane Dicarboxylic Aldehyde) level and the activity improvement of antioxidant enzymes such as super oxygen dehydrogenises, catalase and glutathione peroxidase.
ISSN: 1000-565X
DOI: 10.3969/j.issn.1000-565X.2012.12.026
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