Please use this identifier to cite or link to this item: http://hdl.handle.net/10397/20866
Title: Luminescent cyclometalated platinum(II) complex forms emissive intercalating adducts with double-stranded DNA and RNA : differential emissions and anticancer activities
Authors: Zou, T
Liu, J
Lum, CT
Ma, C
Chan, RCT
Lok, CN
Kwok, WM 
Che, CM
Keywords: Anticancer
DNA
Exciplex emission
Platinum
Topoisomerase I
Issue Date: 2014
Publisher: Wiley-VCH
Source: Angewandte chemie international edition, 2014, v. 53, no. 38, p. 10120-10123 How to cite?
Journal: Angewandte chemie international edition 
Abstract: Luminescent metallo-intercalators are potent biosensors of nucleic acid structure and anticancer agents targeting DNAs. There are few examples of luminescent metallo-intercalators which can simultaneously act as emission probes of nucleic acid structure and display promising anticancer activities. Herein, we describe a luminescent platinum(II) complex, [Pt(?NN)(C¡ÝNtBu)]ClO4 (1 a, H?NN= 6-phenyl-2,2¡¬-bipyridyl), that intercalates between the nucleobases of nucleic acids, accompanied by an increase in emission intensity and/or a significant change in the maximum emission wavelength. The changes in emission properties measured with double-stranded RNA (dsRNA) are different from those with dsDNA used in the binding reactions. Complex 1 a exhibited potent anticancer activity towards cancer cells in vitro and inhibited tumor growth in a mouse model. The stabilization of the topoisomerase I-DNA complex with resulting DNA damage by 1 a is suggested to contribute to its anticancer activity.
URI: http://hdl.handle.net/10397/20866
ISSN: 1433-7851
EISSN: 1521-3773
DOI: 10.1002/anie.201405384
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