Please use this identifier to cite or link to this item: http://hdl.handle.net/10397/20670
Title: Voxel-based analysis of MRI detects abnormal visual cortex in children and adults with amblyopia
Authors: Mendola, JD
Conner, IP
Roy, A
Chan, ST
Schwartz, TL
Odom, JV
Kwong, KK
Keywords: Neural substrate
Pediatric
Plasticity
Strabismus
morphology
Striate cortex
V1
VBM
Issue Date: 2005
Publisher: Wiley-Liss
Source: Human brain mapping, 2005, v. 25, no. 2, p. 222-236 How to cite?
Journal: Human Brain Mapping 
Abstract: Amblyopia, sometimes called "lazy eye," is a relatively common developmental visual disorder well characterized behaviorally; however, the neural substrates associated with amblyopia in humans remain unclear. We hypothesized that abnormalities in the cerebral cortex of subjects with amblyopia exist, possibly as a result of experience-dependent neuronal plasticity. Anatomic magnetic resonance imaging (MRI) and psychophysical vision testing was carried out on 74 subjects divided into two age ranges, 7-12 years and 18-35 years, and three diagnoses, strabismic amblyopia, anisometropic amblyopia, and normal vision. We report a behavioral impairment in contrast sensitivity for subjects with amblyopia, consistent with previous reports. When the high-resolution MRI brain images were analyzed quantitatively with optimized voxel-based morphometry, results indicated that adults and children with amblyopia have decreased gray matter volume in visual cortical regions, including the calcarine sulcus, known to contain primary visual cortex. This finding was confirmed with a separate region-of-interest analysis. For the children with amblyopia, additional gray matter reductions in parietal-occipital areas and ventral temporal cortex were detected, consistent with recent reports that amblyopia can result in spatial location and object processing deficits. These data are the first to provide possible neuroanatomic bases for the loss of binocularity and visual sensitivity in children and adults with amblyopia.
URI: http://hdl.handle.net/10397/20670
ISSN: 1065-9471
DOI: 10.1002/hbm.20109
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