Please use this identifier to cite or link to this item: http://hdl.handle.net/10397/20181
Title: Antioxidants, vegetarian diets and aging
Authors: Wachtel-Galor, S
Siu, PM 
Benzie, IFF 
Issue Date: 2014
Source: In VR Preedy (Ed.), Aging : oxidative stress and dietary antioxidants, p. 81-91. Oxford: Academic Press, 2014
Abstract: Aging is a complex and almost universal biologic phenomenon that increases the risk of disease and death. Exact mechanisms of aging are unresolved, but oxidative stress is a common thread binding the various theories of aging, and is a suggested key underlying factor and driver of the deleterious consequences of human aging in terms of cancer, cardiovascular disease, diabetes, dementia, and other age-related diseases. Oxidative stress can be modulated or opposed by the antioxidant defenses of the body. Many antioxidants found in blood plasma are of dietary origin, and there is convincing evidence that people who habitually take an antioxidant-rich diet live longer, healthier lives. Here we present some of the evidence that oxidative stress is a key factor in aging and age-related disease, and that those who adhere to an antioxidant-rich vegetarian diet have lower oxidative stress and a longer healthspan. Finally, we discuss briefly the possible molecular mechanisms of action of diet-derived antioxidants, with a focus on redox balance and cytoprotective adaptations to pro-oxidant activity of antioxidant phytochemicals.
Keywords: Aging
Antioxidant
Diet
Functional longevity
Healthspan
Oxidative stress
Phytochemicals
Redox balance
ROS
Vegetarian
Publisher: Academic Press
ISBN: 1306489490 (ebk)
9781306489492 (ebk)
9780124059337
DOI: 10.1016/B978-0-12-405933-7.00008-1
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