Please use this identifier to cite or link to this item: http://hdl.handle.net/10397/20137
Title: Silica-modified oligonucleotide-gold nanoparticle conjugate enables closed-tube colorimetric polymerase chain reaction
Authors: Wong, JKF
Yip, SP 
Lee, TMH 
Keywords: colorimetric detection
DNA recognition
gold nanoparticles
polymerase chain reaction
silica coating
Issue Date: 2012
Publisher: Wiley-VCH
Source: Small, 2012, v. 8, no. 2, p. 214-219 How to cite?
Journal: Small 
Abstract: A facile silica coating significantly enhances the thermal stability and polymerase chain reaction (PCR) compatibility of oligonucleotide-gold nanoparticle conjugates, thus enabling colorimetric detection of PCR results in a closed-tube format. This method is specific, sensitive, and generally applicable. Its simplicity, visual readout, and carryover contamination-free features hold promise for point-of-care or on-site DNA testing.
URI: http://hdl.handle.net/10397/20137
ISSN: 1613-6810
EISSN: 1613-6829
DOI: 10.1002/smll.201101925
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