Please use this identifier to cite or link to this item: http://hdl.handle.net/10397/20039
Title: Novel hypoglycemic effects of Ganoderma lucidum water-extract in obese/diabetic (+db/+db) mice
Authors: Seto, SW
Lam, TY
Tam, HL
Au, ALS
Chan, SW
Wu, JH
Yu, PHF
Leung, GPH
Ngai, SM
Yeung, JHK
Leung, PS
Lee, SMY
Kwan, YW
Keywords: Ganoderma lucidum
HMG CoA reductase
PEPCK
Type 2 diabetes mellitus
Issue Date: 2009
Publisher: Elsevier Gmbh, Urban & Fischer Verlag
Source: Phytomedicine, 2009, v. 16, no. 5, p. 426-436 How to cite?
Journal: Phytomedicine 
Abstract: In this study, we evaluated the pharmacological effects of Ganoderma lucidum (G. lucidum) (water-extract) (0.003, 0.03 and 0.3 g/kg, 4-week oral gavage) consumption using the lean (+db/+m) and the obese/diabetic (+db/+db) mice. Different physiological parameters (plasma glucose and insulin levels, lipoproteins-cholesterol levels, phosphoenolpyruvate carboxykinase (PEPCK), 3-hydroxy-3-methylglutaryl coenzyme A reductase (HMG CoA reductase) and isolated aorta relaxation of both species were measured and compared. G. lucidum (0.03 and 0.3 g/kg) lowered the serum glucose level in +db/+db mice after the first week of treatment whereas a reduction was observed in +db/+m mice only fed with 0.3 g/kg of G. lucidum at the fourth week. A higher hepatic PEPCK gene expression was found in +db/+db mice. G. lucidum (0.03 and 0.3 g/kg) markedly reduced the PEPCK expression in +db/+db mice whereas the expression of PEPCK was attenuated in +db/+m mice (0.3 g/kg G. lucidum). HMG CoA reductase protein expression (in both hepatic and extra-hepatic organs) and the serum insulin level were not altered by G. lucidum. These data demonstrate that G. lucidum consumption can provide beneficial effects in treating type 2 diabetes mellitus (T2DM) by lowering the serum glucose levels through the suppression of the hepatic PEPCK gene expression.
URI: http://hdl.handle.net/10397/20039
DOI: 10.1016/j.phymed.2008.10.004
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