Please use this identifier to cite or link to this item: http://hdl.handle.net/10397/19846
Title: Structure and antioxidant activity of a novel poly-N-Acetylhexosamine produced by a medicinal fungus
Authors: Chen, S
Siu, KC
Wang, WQ
Liu, XX
Wu, JY 
Keywords: Antioxidant activity
Cordyceps sinensis
Exopolysaccharide
MS
NMR
Poly-N-Acetylhexosamine
Issue Date: 2013
Publisher: Elsevier Sci Ltd
Source: Carbohydrate polymers, 2013, v. 94, no. 1, p. 332-338 How to cite?
Journal: Carbohydrate Polymers 
Abstract: A novel poly-N-Acetylhexosamine (polyhexNAc) about 6 kDa average molecular weight (MW) was isolated from the low-MW fraction of exopolysaccharide produced by liquid fermentation of a medicinal fungus Cordyceps sinensis Cs-HK1. The composition and linkage of sugar residues were determined by mass spectrometry and methylation analysis, and the anomeric configuration and chain linkage were confirmed by NMR. From the analytical results, the molecular structure was elucidated as a [-4-β-d-ManNAc-(1→3)-β-d-GalNAc-(1→] disaccharide repeating unit in the main chain with a Gal branch occurring randomly at the 3-position of ManNAc. This polyhexNAc showed notable antioxidant activities with a Trolox equivalent antioxidant capacity of 330 μmol Trolox/g, a ferric reducing ability of plasma of 45.7 μmol Fe(II)/g, and significant cytoprotective effect against H2O2-induced PC12 cell injury. This is the first report on the structure and bioactivity of an extracellular amino-polysaccharide from the Cordyceps species.
URI: http://hdl.handle.net/10397/19846
ISSN: 0144-8617
DOI: 10.1016/j.carbpol.2012.12.067
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