Please use this identifier to cite or link to this item: http://hdl.handle.net/10397/19839
Title: Yuehchukene, a bis-indole alkaloid, and cyclophosphamide are active in breast cancer in vitro
Authors: Leung, TWT
Cheng, G
Chui, CH
Ho, SKW
Lau, FY
Tjong, JKJ
Poon, TCC
Tang, JCO 
Tse, WCP
Cheng, KF
Kong, YC
Keywords: Breast cancer
Estrogen
Yuehchukene
Issue Date: 2000
Source: Chemotherapy, 2000, v. 46, no. 1, p. 62-68 How to cite?
Journal: Chemotherapy 
Abstract: Yuehchukene (YCK) is a novel bis-indole alkaloid with weak estrogenic activity. Biochemical studies showed that YCK could attenuate estrogenic action. In this study, the response of MCF-7, an estrogen-receptor-positive breast cancer cell line, under different combinations of estradiol, cyclophosphamide and YCK, was tested. From the dose-response curve, we discovered that 10 -2 M cyclophosphamide, even in its so-called 'bio-inert' form, could inhibit MCF-7 cell growth. However, the cytotoxic effect of cyclophosphamide was lost by reducing its concentration to ~ 1 x 10 -3 M. On the other hand, a low concentration (~ 10 -8-10 -9 M) of YCK was found to potentiate the cytotoxic effect of cyclophosphamide on the MCF-7 cell line. Such an effect was absent in the estrogen-receptor-negative cell line MDA-MB-231. These findings, together with the dual role of a mixed estrogen and anti-estrogen effect, suggested that YCK and cyclophosphamide can be a potential combination in chemo-hormonal therapy for breast cancer.
URI: http://hdl.handle.net/10397/19839
ISSN: 0009-3157
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