Please use this identifier to cite or link to this item: http://hdl.handle.net/10397/19805
Title: Homogeneous sulfation of bagasse cellulose in an ionic liquid and anticoagulation activity
Authors: Wang, ZM
Li, L
Xiao, KJ
Wu, JY 
Keywords: Sugarcane bagasse
Bagasse cellulose sulfates
Anticoagulation
Ionic liquid
Degree of substitution
Issue Date: 2009
Publisher: Elsevier
Source: Bioresource technology, 2009, v. 100, no. 4, p. 1687-1690 How to cite?
Journal: Bioresource technology 
Abstract: Homogeneous sulfation of bagasse cellulose (BC) with chlorosulfonic acid–dimethylformamide was accomplished in an ionic liquid 1-butyl-3-methylimidazolium chloride ([C4mim]Cl). The BCS products from the sulfation had degrees of substitution (DS) in the range of 0.52–2.95 and a simultaneous substitution pattern at C-6, C-2 and C-3 positions. The sulfated BCS attained significant anticoagulation activity, causing a dose-dependent prolongation of coagulation time and inhibition of FIIa and FXa activities in human plasma. The anticoagulation activity of BCS showed a positive correlation with DS, and some of the activity indexes exceeded those of heparin.
URI: http://hdl.handle.net/10397/19805
ISSN: 0960-8524
EISSN: 1873-2976
DOI: 10.1016/j.biortech.2008.09.002
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