Please use this identifier to cite or link to this item: http://hdl.handle.net/10397/19372
Title: The ECM protein LTBP-2 is a suppressor of esophageal squamous cell carcinoma tumor formation but higher tumor expression associates with poor patient outcome
Authors: Chan, SHK
Ko, JMY
Chan, KW
Chan, YP
Tao, Q
Hyytiainen, M
Keski-Oja, J
Law, S
Srivastava, G
Tang, J 
Tsao, SW
Chen, H
Stanbridge, EJ
Lung, ML
Keywords: Antiangiogenesis
ESCC
Extracellular matrix protein
Hypermethylation
Invasion
LOH
LTBP-2
Microcell-mediated chromosome transfer
Migration
Tumor suppressor gene
Issue Date: 2011
Publisher: Wiley-Blackwell
Source: International journal of cancer, 2011, v. 129, no. 3, p. 565-573 How to cite?
Journal: International Journal of Cancer 
Abstract: Our previous studies of chromosome 14 transfer into tumorigenic esophageal squamous cell carcinoma (ESCC) cell line, SLMT, suggested the existence of tumor suppressor genes on chromosome 14. Gene expression profiling of microcell hybrids and the tumor segregants identified an interesting gene, LTBP-2 (latent transforming growth factor ?] binding protein 2), which has been analyzed here for its role in ESCC. LTBP-2 maps to 14q24 and encodes a secreted protein, which is a component of the extracellular matrix microfibrils. LTBP-2 expression was downregulated in ESCC cell lines and tumor tissues. Promoter hypermethylation was found to be involved in LTBP-2 inactivation. Functional studies indicated its tumor-suppressiv
URI: http://hdl.handle.net/10397/19372
ISSN: 0020-7136
DOI: 10.1002/ijc.25698
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