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Title: A 5-fluorouracil-loaded polydioxanone weft-knitted stent for the treatment of colorectal cancer
Authors: Li, G
Chen, Y
Hu, J
Wu, X
Hu, J
He, X
Li, J
Zhao, Z
Chen, Z
Li, Y
Hu, H 
Li, Y 
Lan, P
Keywords: 5-FU-loaded weft-knitted stents
Anti-tumour effect
Drug release
Intestinal stenosis
Invitro and invivo
Issue Date: 2013
Publisher: Elsevier Sci Ltd
Source: Biomaterials, 2013, v. 34, no. 37, p. 9451-9461 How to cite?
Journal: Biomaterials 
Abstract: In-stents restenosis caused by tumour ingrowth is a major problem for patients undergoing stent displacement because the conventional stents often lack a sustained anti-tumour capability. The aim of this paper was to develop a weft-knitted polydioxanone stent which can slow release 5-fluorouracil (5-FU). In order to determine the most suitable drug concentration, the 5-FU safe concentration invivo and appropriate loading percentage in the membranes were investigated, and then 5-FU-loaded poly-l-lactide membranes at concentration of 3.2%, 6.4% and 12.8% were coated onto the stent using electro-spinning method, respectively. The morphology, chemical structure and invitro drug release property of the coating membranes were subsequently examined. Their anti-tumour activity and mechanism were assessed invitro and invivo using a human colorectal cancer cell line HCT-116 and tumour-bearing BALB/c nude mice. The half maximal inhibitory concentration (IC50) and the median lethal dose (LD50) demonstrated that the 6.4% and 12.8% membranes had better anti-tumour effects than pure 5-FU due to the sustainable drug releasing property of the coated membranes on the stent. The membranes possessing appropriate drug loading doses, such as 6.4% or 12.8% also provided better anti-in-stents restenosis effects than other groups tested. Therefore, it is concluded that the drug-loaded stents have great potential for the use in the treatment of intestinal cancers in the future.
ISSN: 0142-9612
DOI: 10.1016/j.biomaterials.2013.08.055
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