Please use this identifier to cite or link to this item: http://hdl.handle.net/10397/19183
Title: Molecular characterisation of a multidrug resistance conjugative plasmid from Vibrio parahaemolyticus
Authors: Liu, M
Wong, MHY
Chen, S 
Keywords: blaPER-1
Multidrug resistance
Novel integron
qnrVC6
Vibrio parahaemolyticus
Issue Date: 2013
Publisher: Elsevier
Source: International journal of antimicrobial agents, 2013, v. 42, no. 6, p. 575-579 How to cite?
Journal: International journal of antimicrobial agents 
Abstract: Vibrio parahaemolyticus is a major causative agent of gastroenteritis and is the leading cause of food-borne illness in Hong Kong. Recent studies of resistance to extended-spectrum β-lactams and fluoroquinolones in V. parahaemolyticus have caused huge concern. This work reports the characterisation of a multidrug resistance conjugative plasmid in V. parahaemolyticus isolated from shrimp samples from Hong Kong. The plasmid is ca. 200 kb and carries multidrug resistance genes, including a novel plasmid-mediated quinolone resistance gene qnrVC6 surrounded by several known and novel insertion sequence (IS) elements, an extended-spectrum β-lactamase gene blaPER-1 mediated by ISCR1, and a ca. 3-kb four-gene cassette (aacA3, catB2, dfrA1 and aadA1) class 1 integron. Transmission of this multidrug resistance conjugative plasmid among Vibrio spp. would compromise the effectiveness of Vibrio infection control and pose a huge threat to public health.
URI: http://hdl.handle.net/10397/19183
ISSN: 0924-8579
EISSN: 1872-7913
DOI: 10.1016/j.ijantimicag.2013.08.014
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