Please use this identifier to cite or link to this item: http://hdl.handle.net/10397/19046
Title: A Potent Multi-functional Neuroprotective Derivative of Tetramethylpyrazine
Authors: Chen, HY
Xu, DP
Tan, GL
Cai, W
Zhang, GX
Cui, W
Wang, JZ
Long, C
Sun, YW
Yu, P
Tsim, KW
Zhang, ZJ
Han, YF 
Wang, YQ
Keywords: J147
Multi-functional neuroprotection
Neurodegenerative disorders
Tetramethylpyrazine
Issue Date: 2015
Publisher: Springer New York LLC
Source: Journal of molecular neuroscience, 2015, v. 56, no. 4, p. 977-987 How to cite?
Journal: Journal of Molecular Neuroscience 
Abstract: Neurodegenerative disorders are one of the leading causes of death among the elderly. Therapeutic approaches with a single target have proven unsuccessful in treating these diseases. Structural combination of multi-functional compounds may lead to a molecule with multiple properties. In this study, we designed and synthesized T-006, a novel analog derived from two multi-functional neuroprotective chemicals, tetramethylpyrazine and J147. The methoxyphenyl group of J147 was replaced by tetramethylpyrazine. Bioactivity evaluation showed that T-006 at very low concentrations had multi-functional neuroprotective effects including rescuing iodoacetic acid-induced neuronal loss, preventing oxidative stress-induced neurotoxicity and reducing glutamate-induced excitotoxicity in vitro. Most importantly, T-006 significantly ameliorated memory impairments in APP/PS1 transgenic mice. These multiple functions of a single molecule suggest that T-006 is a promising novel neuroprotective agent for treating various neurodegenerative disorders, including and in particular Alzheimer��s disease. ? 2015, Springer Science+Business Media New York.
URI: http://hdl.handle.net/10397/19046
ISSN: 8958-8696
DOI: 10.1007/s12031-015-0566-x
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