Please use this identifier to cite or link to this item: http://hdl.handle.net/10397/18915
Title: The synthesis of dendritic BINOL ligands and their applications in the enantioselective Lewis acid catalyzed addition of diethylzinc to aldehydes
Authors: Fan, QH
Liu, GH
Chen, XM
Deng, GJ
Chan, ASC
Issue Date: 2001
Publisher: Pergamon Press
Source: Tetrahedron : asymmetry, 2001, v. 12, no. 11, p. 1559-1565 How to cite?
Journal: Tetrahedron : asymmetry 
Abstract: Novel dendritic chiral BINOL ligands have been synthesized through coupling of MOM-protected 3,3′-dihydroxy-methyl- binaphthol with Fréchet-type polyether benzyl bromide dendrons followed by deprotection of the MOM groups using TsOH. These dendritic chiral BINOL ligands were found to be effective in the enantioselective addition of diethylzinc to benzaldehyde both in the presence and absence of Ti(O-iso-Pr)4. The enantioselectivity decreased with increasing generation in both cases. In the latter case, the dendritic chiral BINOL ligands showed much higher catalytic activity and enantioselectivity than BINOL.
URI: http://hdl.handle.net/10397/18915
ISSN: 0957-4166
EISSN: 1362-511X
DOI: 10.1016/S0957-4166(01)00274-9
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