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Title: Low intensity pulsed ultrasound accelerated bone remodeling during consolidation stage of distraction osteogenesis
Authors: Chan, CW
Qin, L
Lee, KM
Zhang, M 
Cheng, JCY
Leung, KS
Keywords: Bone remodeling
Distraction osteogenesis
Low intensity pulsed ultrasound
Issue Date: 2006
Publisher: John Wiley & Sons
Source: Journal of orthopaedic research, 2006, v. 24, no. 2, p. 263-270 How to cite?
Journal: Journal of orthopaedic research 
Abstract: Bone regeneration in distraction osteogenesis occurs under tensile stress with axial rhythmic distraction after osteotomy. In this study, we evaluated if the low intensity pulsed ultrasound (LIPUS) was also effective on enhancement of bone remodeling during consolidation stage of distraction osteogenesis. Open osteotomy of seventeen 18-week-old female New Zealand rabbit tibiae were performed. The distraction was applied with the rate of 1 mm per day. LIPUS (30 mW/cm2, 1.5 MHz) was delivered for 20 min per day during 4-week consolidation stage (n=10). The animals without treatment served as sham group (n=7). Plain X-ray, peripheral quantitative computational tomography (pQCT), and torsional test were performed. Results showed that smaller radiolucent interzone of LIPUS treatment group was gradually occupied by calcified tissue in plain X-ray at week 2. The bone mineral density (BMD) measured on radiographs increased by 9.18% in the LIPUS group. Bone mineral content (BMC), hard callus volume, and bone strength index (BSI) measured by pQCT were 83%, 116%, and 94%, respectively, in LIPUS group that were significantly greater than those of the controls. At the 4th week, LIPUS-treated callus showed the development of neocorticalization in the proximal and distal region. The BMC, hard callus volume, and BSI of LIPUS group decreased and was not significantly different from control. This was also confirmed by the maximum torque of LIPUS-treated callus (1424.2 ± 457.3 N · mm) obtained at week 4, which did not differ from that of the sham group (1968.8 ± 895.1 N · mm). In conclusion, the effective period of LIPUS treatment was at the initial stage of consolidation, with accelerated bone formation and remodeling.
ISSN: 0736-0266
EISSN: 1554-527X
DOI: 10.1002/jor.20015
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