Please use this identifier to cite or link to this item: http://hdl.handle.net/10397/1877
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dc.contributorDepartment of Electronic and Information Engineering-
dc.creatorWong, KP-
dc.creatorMeikle, SR-
dc.creatorFeng, DD-
dc.creatorFulham, MJ-
dc.date.accessioned2014-12-11T08:25:39Z-
dc.date.available2014-12-11T08:25:39Z-
dc.identifier.issn0018-9499-
dc.identifier.urihttp://hdl.handle.net/10397/1877-
dc.language.isoenen_US
dc.publisherInstitute of Electrical and Electronics Engineersen_US
dc.rights© 2002 IEEE. Personal use of this material is permitted. However, permission to reprint/republish this material for advertising or promotional purposes or for creating new collective works for resale or redistribution to servers or lists, or to reuse any copyrighted component of this work in other works must be obtained from the IEEE.en_US
dc.rightsThis material is presented to ensure timely dissemination of scholarly and technical work. Copyright and all rights therein are retained by authors or by other copyright holders. All persons copying this information are expected to adhere to the terms and constraints invoked by each author's copyright. In most cases, these works may not be reposted without the explicit permission of the copyright holder.en_US
dc.subjectImpulse response functionen_US
dc.subjectInput functionen_US
dc.subjectKinetic parameter estimationen_US
dc.subjectNonlinear least squaresen_US
dc.subjectSimulated annealingen_US
dc.subjectSingle-photon emission computed tomography (SPECT)en_US
dc.subjectTeboroximeen_US
dc.titleEstimation of input function and kinetic parameters using simulated annealing : application in a flow modelen_US
dc.typeJournal/Magazine Articleen_US
dc.description.otherinformationAuthor name used in this publication: Dagan Fengen_US
dc.description.otherinformationCentre for Multimedia Signal Processing, Department of Electronic and Information Engineeringen_US
dc.identifier.spage707-
dc.identifier.epage713-
dc.identifier.volume49-
dc.identifier.issue3-
dc.identifier.doi10.1109/TNS.2002.1039552-
dcterms.abstractAccurate determination of the input function is essential for absolute quantification of physiological parameters in positron emission tomography and single-photon emission computed tomography imaging, but it requires an invasive and tedious procedure of blood sampling that is impractical in clinical studies. We previously proposed a technique that estimates simultaneously kinetic parameters and the input function from the tissue impulse response functions and requires two blood samples. A nonlinear least squares method estimated all the parameters in the impulse response functions and the input function but failed occasionally due to high noise levels in the data, causing an ill-conditioned cost function. This paper investigates the feasibility of applying a Monte Carlo method called simulated annealing to estimate kinetic parameters in the impulse response functions and the input function. Time-activity curves of teboroxime, which is very sensitive to changes in the input function, were simulated based on published data obtained from a canine model. The equations describing the tracer kinetics in different regions were minimized simultaneously by simulated annealing and nonlinear least squares. We found that the physiological parameters obtained with simulated annealing are accurate, and the estimated input function more closely resembled the simulated curve. We conclude that simulated annealing reduces bias in the estimation of physiological parameters and determination of the input function.-
dcterms.accessRightsopen accessen_US
dcterms.bibliographicCitationIEEE transactions on nuclear science, June 2002, v. 49, no. 3, p. 707-713-
dcterms.isPartOfIEEE transactions on nuclear science-
dcterms.issued2002-06-
dc.identifier.isiWOS:000178670800015-
dc.identifier.scopus2-s2.0-0036624547-
dc.identifier.eissn1558-1578-
dc.identifier.rosgroupidr14150-
dc.description.ros2002-2003 > Academic research: refereed > Publication in refereed journal-
dc.description.oaVersion of Recorden_US
dc.identifier.FolderNumberOA_IR/PIRAen_US
dc.description.pubStatusPublisheden_US
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