Please use this identifier to cite or link to this item: http://hdl.handle.net/10397/18614
Title: Discovery of a drug-like G-quadruplex binding ligand by high-throughput docking
Authors: Ma, DL
Lai, TS
Chan, FY
Chung, WH
Abagyan, R
Leung, YC 
Wong, KY 
Keywords: DNA
G-quadruplexes
High-throughput docking
Ligands
Selectivity
Issue Date: 2008
Publisher: Wiley-VCH
Source: ChemMedChem, 2008, v. 3, no. 6, p. 881-884 How to cite?
Journal: Chemmedchem 
Abstract: (Figure Presented) A new G-quadruplex binding ligand, namely 1H-pyrazole-3-carboxy-4-methyl-5-phenyl-(1H-indol-3-ylmethylene)hydrazide, was identified from a database of 100 000 drug-like compounds by in silico high-throughput docking. This compound was demonstrated experimentally to be an effective stabilizer of G-quadruplex DNA; it exhibits high selectivity for G-quadruplex over duplex DNA.
URI: http://hdl.handle.net/10397/18614
ISSN: 1860-7179
EISSN: 1860-7187
DOI: 10.1002/cmdc.200700342
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