Please use this identifier to cite or link to this item: http://hdl.handle.net/10397/18431
Title: Enantioselective hydrogenation of alpha-aminomethylacrylates containing a free N-H group for the synthesis of beta-amino acid derivatives
Authors: Qiu, L
Prashad, M
Hu, B
Prasad, K
Repic, O
Blacklock, TJ
Kwong, FY 
Kok, SHL
Lee, HW
Chan, ASC
Keywords: Asymmetric catalysis
Baylis-Hillman reaction
Issue Date: 2007
Publisher: National Academy of Sciences
Source: Proceedings of the National Academy of Sciences of the United States of America, 2007, v. 104, no. 43, p. 16787-16792 How to cite?
Journal: Proceedings of the National Academy of Sciences of the United States of America 
Abstract: We describe highly enantioselective synthesis of beta-amino acid derivatives (1a-c) using asymmetric hydrogenation of alpha-aminomethylacrylates (2a-c), which contain a free basic N-H group, as the key step. The alpha-aminomethylacrylates (2a-c) were prepared using the Baylis-Hillman reaction of an appropriate alclehyde with methyl acrylate followed by acetylation of the resulting allylic alcohols (4a-b) and S(N)2'-type amination of the allylic acetates (3a-b).
URI: http://hdl.handle.net/10397/18431
ISSN: 0027-8424
EISSN: 1091-6490
DOI: 10.1073/pnas.0704461104
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