Please use this identifier to cite or link to this item: http://hdl.handle.net/10397/18365
Title: An asymmetric approach toward chiral multicyclic spirooxindoles from isothiocyanato oxindoles and unsaturated pyrazolones by a chiral tertiary amine thiourea catalyst
Authors: Chen, Q
Liang, J
Wang, S
Wang, D
Wang, R
Issue Date: 2013
Source: Chemical communications, 2013, v. 49, no. 16, p. 1657-1659
Abstract: The first organocatalytic Michael-cyclization cascade reaction between isothiocyanato oxindoles and unsaturated pyrazolones has been developed. The multicyclic spiro[oxindole/thiobutyrolactam/pyrazolone] core structures containing three contiguous stereogenic centers, including two spiro quaternary centers, were prepared with excellent diastereo- (up to >20:1) and enantioselectivities (up to 99% ee).
Publisher: Royal Society of Chemistry
Journal: Chemical communications 
ISSN: 1359-7345
EISSN: 1364-548X
DOI: 10.1039/c3cc38386e
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