Please use this identifier to cite or link to this item: http://hdl.handle.net/10397/18167
Title: Dopamine release rather than content in the caudate putamen is associated with behavioral changes in the iron rat model of Parkinson's disease
Authors: Xie, J
Jiang, H
Chen, W
Qian, ZM
Keywords: Desferrioxamine
Dopamine release and content
Intranigral iron injection
Nigrostriatal dopaminergic neurons
Parkinson's disease
Issue Date: 2003
Source: Experimental neurology, 2003, v. 182, no. 2, p. 483-489 How to cite?
Journal: Experimental Neurology 
Abstract: The effects of intranigral iron injection on dopamine (DA) release and content in the caudate putamen (CPu) and their relationship to DA-related behavioral response were investigated in rats. Different concentrations of FeCl3 (10, 20, and 40 μg) and saline were injected separately into the left substantia nigra. In some experiments, rats were pretreated with desferrioxamine or saline before iron injection. After 3 weeks, changes in behavioral response, DA release, and DA content in the CPu were determined. In all iron injection groups (10, 20, and 40 μg), DA content in the lesioned side of the brain was significantly decreased, showing a significant linear correlation (R2 = 0.981, P = 0.01), and DA turnover ratio significantly increased (both P = 0.01, 0.01 and 0.001 vs unlesioned sides, respectively). However, injection dosages of 10 or 20 μg of iron did not lead to significant changes in DA release in the CPu or in behavioral response. At the 40-μg dosage, it was found that DA release in the lesioned side and rearing activity both were significantly reduced (all P = 0.01 vs unlesioned side or control) and apomorphine-induced rotation was observed. Pretreatment with desferrioxamine significantly inhibited the effect of iron on DA release and content. These results demonstrate that iron injection can damage dopaminergic neurons and suggest that DA release, rather than DA content, in the CPu is associated with DA-related behavioral changes in this PD model.
URI: http://hdl.handle.net/10397/18167
ISSN: 0014-4886
DOI: 10.1016/S0014-4886(03)00123-7
Appears in Collections:Journal/Magazine Article

Access
View full-text via PolyU eLinks SFX Query
Show full item record

SCOPUSTM   
Citations

26
Last Week
0
Last month
0
Citations as of Apr 19, 2018

WEB OF SCIENCETM
Citations

19
Last Week
0
Last month
0
Citations as of Apr 13, 2018

Page view(s)

53
Last Week
0
Last month
Citations as of Apr 16, 2018

Google ScholarTM

Check

Altmetric


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.