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Title: Detection of glaucomatous damage using multifocal ERG
Authors: Chan, HHL 
Keywords: Glaucoma
Low contrast
Multifocal ERG
Issue Date: 2005
Publisher: Wiley-Blackwell
Source: Clinical and experimental optometry, 2005, v. 88, no. 6, p. 410-414 How to cite?
Journal: Clinical and experimental optometry 
Abstract: The first-order kernel analysis in multifocal electroretinogram (mfERG) using low contrast stimulation is suggested as a way to detect the inner retinal responses in animal studies. In this case report, this protocol is applied to human patients with glaucoma to demonstrate the possibility of using mfERG as a tool to detect glaucomatous damage. Two patients with glaucoma were recruited and had mfERG measurements with the 103-scaled hexagonal stimulus pattern at low (50 per cent) contrast. Their responses were analysed and compared with those from normal subjects with the mfERG measured under the same condition. In the normal subjects, there were obvious oscillatory components on the ascending and descending limbs of the first-order kernel response to 50 per cent contrast. In the glaucomatous patients, the oscillatory component on the descending limb was obviously diminished. In addition, this component was significantly diminished in the quadrant with a glaucomatous visual field defect. This suggests that the low-contrast stimulation condition in mfERG measurement may provide a good way to detect glaucomatous damage and this may help in clinical diagnosis of glaucoma.
ISSN: 0816-4622
EISSN: 1444-0938
DOI: 10.1111/j.1444-0938.2005.tb05108.x
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