Please use this identifier to cite or link to this item: http://hdl.handle.net/10397/17952
Title: Photodynamic therapy of cancer - Challenges of multidrug resistance
Authors: Huang, Z
Hsu, YC
Li, LB
Wang, LW
Song, XD
Yow, CMN
Lei, X
Musani, AI
Luo, RC
Day, BJ
Keywords: Cancer
Multidrug resistance
Photodynamic therapy
Photosensitizer
Issue Date: 2015
Publisher: World Scientific Publishing Co. Pte Ltd
Source: Journal of innovative optical health sciences, 2015, v. 8, no. 1, 1530002 How to cite?
Journal: Journal of Innovative Optical Health Sciences 
Abstract: Photodynamic therapy (PDT) of cancer is a two-step drug-device combination modality, which involves the topical or systemic administration of a photosensitizer followed by light illumination of cancer site. In the presence of oxygen molecules, the light illumination of photosensitizer (PS) can lead to the generation of cytotoxic reactive oxygen species (ROS) and consequently destroy cancer. Similar to many other anticancer therapies, PDT is also subject to intrinsic cancer resistance mediated by multidrug resistance (MDR) mechanisms. This paper will review the recent progress in understanding the interaction between MDR transporters and PS uptake. The strategies that can be used in a clinical setting to overcome or bypass MDR will also be discussed.
URI: http://hdl.handle.net/10397/17952
ISSN: 1793-5458
DOI: 10.1142/S1793545815300025
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