Please use this identifier to cite or link to this item: http://hdl.handle.net/10397/17783
Title: Advanced technologies for studying circulating tumor cells at the protein level
Authors: Chan, CML
Au, TCC
Chan, ATC
Ma, BBY
Tsui, NBY
Ng, SSM
Hui, EP
Chan, LWC 
Ho, WS
Yung, BYM 
Wong, SCC 
Keywords: Cellsearch
Circulating tumor cells
CTC-chip
EPISPOT
Immunomagnetic bead
Proteomic
Issue Date: 2013
Publisher: Future Drugs Ltd
Source: Expert review of proteomics, 2013, v. 10, no. 6, p. 579-589 How to cite?
Journal: Expert review of proteomics 
Abstract: Metastasis is the main cause of cancer death. As the tumor progresses, cells from the primary tumor site are shed into the bloodstream as circulating tumor cells (CTCs). Eventually, these cells colonize other organs and form distant metastases. It is therefore imperative that we gain a better understanding of the biological characteristics of CTCs for development of novel treatment modalities to minimize metastasis-associated cancer deaths. In recent years, rapid developments in technologies for the study of CTCs have taken place. We now have a variety of tools for the isolation and examination of CTCs which were not available before. This review introduces some commonly used protein markers in CTC investigations and summarizes a few advanced technologies which have been successfully applied for studying CTC biology at the protein level.
URI: http://hdl.handle.net/10397/17783
ISSN: 1478-9450
DOI: 10.1586/14789450.2013.858021
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