Please use this identifier to cite or link to this item: http://hdl.handle.net/10397/17694
Title: Desirability function approach for the optimization of microwave-assisted extraction of saikosaponins from Radix Bupleuri
Authors: Hu, Z
Cai, M
Liang, HH 
Keywords: Desirability function
Microwave-assisted extraction
Optimization
Response surface methodology
Saikosaponin
Issue Date: 2008
Publisher: Pergamon Press
Source: Separation and purification technology, 2008, v. 61, no. 3, p. 266-275 How to cite?
Journal: Separation and purification technology 
Abstract: Microwave-assisted extraction (MAE) was applied to the extraction of saikosaponin a, c and d from Radix Bupleuri. Several operating parameters, namely microwave power, time, temperature and ethanol concentration, were optimized using response surface methodology (RSM) with a central composite rotatable design (CCRD). The ethanol concentration and time were found to be the most significant factors (p < 0.0001) for the extraction of all three saikosaponins. By using the desirability function approach, the optimum MAE conditions to obtain desirable extraction yields for all these saikosaponins simultaneously were found at the microwave power of 360-400 W, ethanol concentration of 47-50%, temperature of 73-74 °C and time of 5.8-6.0 min. At these conditions, the yields from the verification experiments were 96.18-96.91% for saikosaponin a, 95.05-95.71% for saikosaponin c and 97.05-97.25% for saikosaponin d, which were in good agreement with the predicted values.
URI: http://hdl.handle.net/10397/17694
ISSN: 1383-5866
EISSN: 1873-3794
DOI: 10.1016/j.seppur.2007.10.016
Appears in Collections:Journal/Magazine Article

Access
View full-text via PolyU eLinks SFX Query
Show full item record

SCOPUSTM   
Citations

39
Last Week
0
Last month
0
Citations as of Jul 29, 2017

WEB OF SCIENCETM
Citations

31
Last Week
0
Last month
1
Citations as of Aug 15, 2017

Page view(s)

40
Last Week
2
Last month
Checked on Aug 14, 2017

Google ScholarTM

Check

Altmetric



Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.