Please use this identifier to cite or link to this item: http://hdl.handle.net/10397/17356
Title: Fabrication of silk fibroin nanoparticles for controlled drug delivery
Authors: Zhao, Z
Chen, A
Li, Y 
Hu, J
Liu, X
Li, J
Zhang, Y
Li, G
Zheng, Z 
Keywords: Drug delivery
Indomethacin
Nanoparticles
Silk fibroin
Supercritical CO 2
Issue Date: 2012
Publisher: Springer
Source: Journal of nanoparticle research, 2012, v. 14, no. 4, 736 How to cite?
Journal: Journal of Nanoparticle Research 
Abstract: A novel solution-enhanced dispersion by supercritical CO 2 (SEDS) was employed to prepare silk fibroin (SF) nanoparticles. The resulting SF nanoparticles exhibited a good spherical shape, a smooth surface, and a narrow particle size distribution with a mean particle diameter of about 50 nm. The results of X-ray powder diffraction, thermo gravimetry- differential scanning calorimetry, and Fourier transform infrared spectroscopy analysis of the SF nanoparticles before and after ethanol treatment indicated conformation transition of SF nanoparticles from random coil to β-sheet form and thus water insolubility. The MTS assay also suggested that the SF nanoparticles after ethanol treatment imposed no toxicity. A non-steroidal anti-inflammatory drug, indomethacin (IDMC), was chosen as the model drug and was encapsulated in SF nanoparticles by the SEDS process. The resulting IDMC-SF nanoparticles, after ethanol treatment, possessed a theoretical average drug load of 20%, an actual drug load of 2.05%, and an encapsulation efficiency of 10.23%. In vitro IDMC release from the IDMC-SF nanoparticles after ethanol treatment showed a significantly sustained release over 2 days. These studies of SF nanoparticles indicated the suitability of the SF nanoparticles prepared by the SEDS process as a biocompatible carrier to deliver drugs and also the feasibility of using the SEDS process to reach the goal of co-precipitation of drug and SF as composite nanoparticles for controlled drug delivery.
URI: http://hdl.handle.net/10397/17356
DOI: 10.1007/s11051-012-0736-5
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