Please use this identifier to cite or link to this item: http://hdl.handle.net/10397/17200
Title: Melatonin protects against cardiac toxicity of doxorubicin in rat
Authors: Xu, MF
Ho, S
Qian, ZM
Tang, PL
Issue Date: 2001
Publisher: Munksgaard Int Publ Ltd
Source: Journal of pineal research, 2001, v. 31, no. 4, p. 301-307 How to cite?
Journal: Journal of Pineal Research 
Abstract: Doxorubicin (DOX) is commonly used for the treatment of hematological and solid tumors. However, there are serious toxic effects on the cardiovascular system, which limits the application of the drug. Recently, melatonin has been reported to have immunomodulatory effect in addition to lowering cholesterol levels as well as inhibiting malignant tumors. In this study, the effect of melatonin against the toxicity of doxorubicin was investigated in rats. Hemodynamic function, pathological and biochemical changes were determined in different treated hearts. Our findings showed that a significant protection by melatonin (6 mg kg- 1 for 15 days, cumulative dose of 90 mg kg - 1) against the DOX-induced toxicity was observed. Cardiac function was improved and lipid peroxidation decreased after melatonin treatment. It is concluded that melatonin provides protection against doxorubicin toxicity via an attenuation of lipid peroxidation.
URI: http://hdl.handle.net/10397/17200
ISSN: 0742-3098
DOI: 10.1034/j.1600-079X.2001.310403.x
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