Please use this identifier to cite or link to this item: http://hdl.handle.net/10397/17116
Title: Preparation of 8-hydroxyquinoline derivatives as potential antibiotics against Staphylococcus aureus
Authors: Lam, KH
Gambari, R
Lee, KKH
Chen, YX
Kok, SHL
Wong, RSM
Lau, FY
Cheng, CH
Wong, WY
Bian, ZX
Chan, ASC
Tang, JCO 
Chui, CH
Keywords: Antibacterial agents
Antibiotics
Quinolines
Staphylococcus aureus
Issue Date: 2013
Publisher: Pergamon Press
Journal: Bioorganic & medicinal chemistry letters 
Abstract: This work describes the preparation of quinoline compounds as possible anti-bacterial agents. The synthesized quinoline derivatives show anti-bacterial activity towards Staphylococcus aureus. It is interesting to observe that the synthetic 5,7-dibromo-2-methylquinolin-8-ol (4) shows a similar minimum inhibitory concentration of 6.25 μg/mL as compared to that of methicillin (3.125 μg/mL) against Staphylococcus aureus.
URI: http://hdl.handle.net/10397/17116
ISSN: 0960-894X
EISSN: 1464-3405
DOI: 10.1016/j.bmcl.2013.10.072
Appears in Collections:Journal/Magazine Article

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