Please use this identifier to cite or link to this item: http://hdl.handle.net/10397/17097
Title: Comparison of catechin profiles in human plasma and urine after single dosing and regular intake of green tea (Camellia sinensis)
Authors: Fung, ST
Ho, CK
Choi, SW
Chung, WY
Benzie, IFF 
Keywords: Antioxidants
Bioavailability
Biotransformation
Catechins
Epigallocatechin gallate
Green tea
Polyphenols
Issue Date: 2013
Publisher: Cambridge University Press
Source: British journal of nutrition, 2013, v. 109, no. 12, p. 2199-2207 How to cite?
Journal: British journal of nutrition 
Abstract: Green tea (Camellia sinensis) catechin profiles in plasma and urine following single dosing and regular ingestion of green tea are not clear. We performed a placebo-controlled intervention study with sixteen healthy volunteers to determine changes in total and free catechins after a single dose and following 1 week of twice-daily green tea. Blood and urine samples were collected before (fasting) and after (60 and 120 min for blood; 90 and 180 min for urine) drinking 200 ml of 1·5 % (w/v) green tea or water (n 8 each), and fasting samples were again collected after 7 d of 150 ml of 1 % (w/v) supplemental green tea or water twice daily. After a 4-week washout, subjects were crossed onto the other treatment and procedures repeated. Plasma results at 1 h post-ingestion showed elevated (P< 0·05) mean epigallocatechin gallate (EGCG; 310 (sd 117) nmol/l; all in free form), epigallocatechin (EGC; 192 (sd 67) nmol/l; 30 % free) and epicatechin gallate (ECG; 134 (sd 51) nmol/l; 75 % free). Fasting plasma after 7 d of regular intake showed increased (P< 0·05) EGCG (80 v. 15 nmol/l at baseline) and ECG (120 v. 40 nmol/l), with ≥ 90 % of both in their conjugated forms. Total EGC was < 10 nmol/l. Post-ingestion conjugation and renal loss of EGC and epicatechin were rapid and high, but were negligible for EGCG and ECG. In the green tea consumed, the content was EGCG >EGC >ECG, and the acute plasma response mirrored this. However, after chronic consumption there was almost no EGC found in fasting plasma, some EGCG was present, but a rather high level of ECG was maintained.
URI: http://hdl.handle.net/10397/17097
ISSN: 0007-1145
EISSN: 1475-2662
DOI: 10.1017/S0007114512004370
Appears in Collections:Journal/Magazine Article

Access
View full-text via PolyU eLinks SFX Query
Show full item record

SCOPUSTM   
Citations

17
Last Week
0
Last month
1
Citations as of Aug 20, 2017

WEB OF SCIENCETM
Citations

13
Last Week
0
Last month
1
Citations as of Aug 20, 2017

Page view(s)

49
Last Week
2
Last month
Checked on Aug 20, 2017

Google ScholarTM

Check

Altmetric



Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.