Please use this identifier to cite or link to this item: http://hdl.handle.net/10397/17094
Title: Up-regulation of HIF-1 alpha expression induced by ginkgolides in hypoxic neurons
Authors: Zhu, L
Wu, XM
Yang, L
Du, F
Qian, ZM
Keywords: Neuroprotection
Ginkgolides
Hypoxia and ischemia
Cell viability
Lactate dehydrogenase (LDH) release
HIF-1 alpha expression
Primary cortical neuron
Issue Date: 2007
Publisher: Elsevier
Source: Brain research, 2007, v. 1166, p. 1-8 How to cite?
Journal: Brain research 
Abstract: Hypoxia-inducible factor-1 (HIF-1) is a master regulator of cellular and systemic oxygen homeostasis. Recently, we demonstrated that ginkgolides, the main constituents of the non-flavone fraction of the standardized Ginkgo biloba (Ginkgoaceae) extract EGb 761, have a significant protective role against chemical and physical hypoxia-induced injury in neurons and PC12 cells. Based on the findings and the function of HIF-1 as a master regulator of oxygen homeostasis, we speculate that the protective role of ginkgolides might be mediated by HIF-1. In this study, we therefore investigated the effects of ginkgolides on the expression of HIF-1 alpha, the cell viability and the lactate dehydrogenase (LDH) release in the hypoxic cortical neuron. We demonstrated that ginkgolides significantly increase the expression of HIF-1a and the cell viability as well as decrease the release of LDH in the hypoxic neuron. The findings suggested that the neuroprotective role of ginkgolides against hypoxia-induced injury might be associated with its role to up-regulate the expression of HIF-1a in the hypoxic neurons.
URI: http://hdl.handle.net/10397/17094
ISSN: 0006-8993
EISSN: 1872-6240
DOI: 10.1016/j.brainres.2007.07.003
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