Please use this identifier to cite or link to this item: http://hdl.handle.net/10397/17073
Title: Dual-modal fluorescent/magnetic bioprobes based on small sized upconversion nanoparticles of amine-functionalized BaGdF5:Yb/Er
Authors: Zeng, S
Tsang, MK
Chan, CF
Wong, KL
Fei, B 
Hao, J 
Issue Date: 2012
Publisher: Royal Society of Chemistry
Source: Nanoscale, 2012, v. 4, no. 16, p. 5118-5124 How to cite?
Journal: Nanoscale 
Abstract: A new type of BaGdF5:Yb/Er nanoprobe for dual-modal fluorescent and magnetic resonance imaging (MRI) is demonstrated. Water soluble and amine-functionalized BaGdF5:Yb/Er nanoparticles (NPs) with average size of about 10 nm were synthesized by a facile one-pot hydrothermal method. The in vitro up-converted emission of BaGdF5:Yb/Er NPs is observed in HeLa cells with near-infrared excitation at 980 nm and served as a fluorescent label. In addition, the cytotoxicity assay in HeLa cells shows low cell toxicity of the amine-functionalized BaGdF5:Yb/Er NPs. Moreover, these BaGdF5 NPs exhibit excellent intrinsic paramagnetic properties and enhanced T-1-weighted MRI images with increased concentrations of BaGdF5 NPs. Therefore, these results suggest that the amine-functionalized BaGdF5 NPs with an optimized size and low cell toxicity are promising dual-modal bioprobes for optical bioimaging and MRI.
URI: http://hdl.handle.net/10397/17073
ISSN: 2040-3364
EISSN: 2040-3372
DOI: 10.1039/c2nr31294h
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