Please use this identifier to cite or link to this item: http://hdl.handle.net/10397/16975
Title: Water-soluble derivative of propolis mitigates scopolamine-induced learning and memory impairment in mice
Authors: Chen, J
Long, Y
Han, M
Wang, T
Chen, Q
Wang, R
Keywords: Acetylcholinesterase
Amnesia
Flavonoids
Morris water maze
Propolis
Scopolamine
Issue Date: 2008
Publisher: Pergamon-Elsevier Science Ltd
Source: Pharmacology biochemistry and behavior, 2008, v. 90, no. 3, p. 441-446 How to cite?
Journal: Pharmacology Biochemistry and Behavior 
Abstract: The water-soluble derivative of propolis (WSDP) was prepared from fresh Chinese propolis. Its major constituents were identified by high performance liquid chromatography (HPLC) analysis. It has been reported that propolis possessed a broad spectrum of biological activities but including few studies on learning and memory by now. Thus, this study was aimed to investigate the effect of WSDP on scopolamine-induced learning and memory impairment in mice. WSDP (50 mg/kg, 100 mg/kg) was given by intragastric administration (i.g.) 40 min prior to the intraperitoneal (i.p.) injection of scopolamine (1 mg/kg).The effect on amnesia was investigated with both hidden-platform acquisition training and probe trial testing in Morris water maze test. The results from 100 mg/kg WSDP group showed significant mitigation scopolamine-induced amnesia in mice. Furthermore, WSDP's effect on the acetylcholinesterase (AChE) activity in the cerebral cortex and hippocampus was also assayed. As a result, WSDP (100 mg/kg) significantly inhibited AChE activity in the hippocampus of scopolamine-treated mice. These results indicated that WSDP may mitigate amnesia in vivo through inhibition of AChE activity in the hippocampus, which suggested propolis may have potential as a pharmaceutical of brain protection with elderly population for preventing Alzheimer's disease (AD) and other neurodegenerative diseases.
URI: http://hdl.handle.net/10397/16975
DOI: 10.1016/j.pbb.2008.03.029
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