Please use this identifier to cite or link to this item: http://hdl.handle.net/10397/16969
Title: 9-Substituted berberine derivatives as G-quadruplex stabilizing ligands in telomeric DNA
Authors: Zhang, WJ
Ou, TM
Lu, YJ
Huang, YY
Wu, WB
Huang, ZS
Zhou, JL
Wong, KY 
Gu, LQ
Keywords: 9-Substituted berberine
Synthesis
Telomerase inhibitor
Telomeric G-quadruplex DNA
Issue Date: 2007
Source: Bioorganic and medicinal chemistry, 2007, v. 15, no. 16, p. 5493-5501 How to cite?
Journal: Bioorganic and Medicinal Chemistry 
Abstract: The interaction of berberine and its 9-substituted derivatives with human telomeric DNA d[G3(T2AG3)3](telo21) has been investigated via CD spectroscopy, fluorescence spectroscopy, PCR-stop assay, competitive dialysis, and telomerase repeat amplification protocol (TRAP) assay. The results indicated that these semisynthesized compounds could induce and stabilize the formation of anti-parallel G-quadruplex of telomeric DNA in the presence or absence of metal cations. Compared with berberine, the 9-substituted derivatives exhibit stronger binding affinity with G-quadruplex and higher inhibitory activity for telomerase. Introduction of a side chain with proper length of methylene and terminal amino group to the 9-position of berberine would significantly strengthen the binding affinity with G-quadruplex, resulting in increasing inhibitory effects on the amplification of telo21 DNA and on the telomerase activity.
URI: http://hdl.handle.net/10397/16969
ISSN: 0968-0896
DOI: 10.1016/j.bmc.2007.05.050
Appears in Collections:Journal/Magazine Article

Access
View full-text via PolyU eLinks SFX Query
Show full item record

SCOPUSTM   
Citations

92
Last Week
0
Last month
4
Citations as of Aug 20, 2017

WEB OF SCIENCETM
Citations

88
Last Week
0
Last month
4
Citations as of Aug 20, 2017

Page view(s)

51
Last Week
3
Last month
Checked on Aug 20, 2017

Google ScholarTM

Check

Altmetric



Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.