Please use this identifier to cite or link to this item: http://hdl.handle.net/10397/16917
Title: Targeted drug delivery via the transferrin receptor-mediated endocytosis pathway
Authors: Qian, ZM
Li, H
Sun, H
Ho, K
Issue Date: 2002
Publisher: Amer Soc Pharmacology Experimental Therapeutics
Source: Pharmacological reviews, 2002, v. 54, no. 4, p. 561-587 How to cite?
Journal: Pharmacological Reviews 
Abstract: The membrane transferrin receptor-mediated endocytosis or internalization of the complex of transferrin bound iron and the transferrin receptor is the major route of cellular iron uptake. This efficient cellular uptake pathway has been exploited for the site-specific delivery not only of anticancer drugs and proteins, but also of therapeutic genes into proliferating malignant cells that overexpress the transferrin receptors. This is achieved either chemically by conjugation of transferrin with therapeutic drugs, proteins, or genetically by infusion of therapeutic peptides or proteins into the structure of transferrin. The resulting conjugates significantly improve the cytotoxicity and selectivity of the drugs. The coupling of DNA to transferrin via a polycation or liposome serves as a potential alternative to viral vector for gene therapy. Moreover, the OX26 monoclonal antibody against the rat transferrin receptor offers great promise in the delivery of therapeutic agents across the blood-brain barrier to the brain.
URI: http://hdl.handle.net/10397/16917
ISSN: 0031-6997
DOI: 10.1124/pr.54.4.561
Appears in Collections:Journal/Magazine Article

Access
View full-text via PolyU eLinks SFX Query
Show full item record

SCOPUSTM   
Citations

632
Last Week
4
Last month
8
Citations as of May 20, 2017

WEB OF SCIENCETM
Citations

565
Last Week
2
Last month
6
Citations as of May 21, 2017

Page view(s)

26
Last Week
1
Last month
Checked on May 21, 2017

Google ScholarTM

Check

Altmetric



Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.