Please use this identifier to cite or link to this item: http://hdl.handle.net/10397/16911
Title: Development of calendula oil/chitosan microcapsules and their biological safety evaluation
Authors: Lam, PL
Yuen, MCW
Kan, CW 
Wong, RSM
Cheng, GYM
Lam, KH
Gambari, R
Kok, SHL
Chui, CH
Issue Date: 2012
Source: Australian journal of chemistry, 2012, v. 65, no. 1, p. 72-80
Abstract: Chitosan microcapsules containing calendula oil are prepared by a simple coacervation method. The results show that the performance of the microcapsules, including encapsulation efficiency and particle size, is affected by the change of various processing parameters of microcapsule manufacture. Under the optimal parameter combinations: the chitosan concentration is 1.5% w/v; the core/wall ratio is 0.1gmL -1; the stirring speed is 1200rpm; and the pH value is 10. The compositions and surface morphology of the microcapsules are examined using scanning electron microscope and FTIR spectroscopy. The in vitro cytotoxicity evaluation demonstrates that the microcapsules exhibit no significant cytotoxic effects on human keratinocytes. The in vivo toxicology analysis on mice proves that the microcapsules do not exert any significant necrosis to the liver. It is suggested that our microcapsules could be used as a safe drug carrier both topically and orally.
Publisher: Csiro Publishing
Journal: Australian Journal of Chemistry 
DOI: 10.1071/CH11386
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