Please use this identifier to cite or link to this item: http://hdl.handle.net/10397/16725
Title: New chiral monophosphite ligands containing BINOL and/or H8-BINOL bearing adamantyl substituents: effect of ligand scaffold on the enantioselective 1,4-conjugate addition of diethylzinc to cyclic enones
Authors: Wan, B
Kwong, FY 
Wang, L
Xu, L
Zhao, Q
Xing, A
Keywords: Adamantyl
Copper salt
Cyclic enone
Enantioselective 1,4-conjugate addition
H8-binaphtyl
Phosphite ligand
Issue Date: 2011
Publisher: 科学出版社
Source: 催化学报 (Chinese journal of catalysis), 2011, v. 32, no. 1, p. 80-85 How to cite?
Journal: 催化学报 (Chinese journal of catalysis) 
Abstract: A series of new bulky monophosphite ligands were synthesized from axially chiral BINOL/H8-BINOL (BINOL: 1-(2-hydroxynaphthalen-1-yl)naphthalen-2-ol) and highly sterically hindered adamantylcarbonyl chloride. The effectiveness of these ligands was evaluated by the Cu-catalyzed asymmetric 1,4-conjugate addition of diethylzinc to cyclic enones with enantioselectivities of up to 79% ee. The results showed that a ligand structure comprising a partially hydrogenated 2,2'-(1,1'-binaphthyl)phosphite scaffold and an adamantyl moiety was effective in improving the enantioselectivity.
URI: http://hdl.handle.net/10397/16725
ISSN: 0253-9837
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