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Title: Mechanism of anticancer effects of antimicrobial peptides
Authors: Liu, X
Li, Y 
Li, Z
Lan, X
Leung, PHM 
Li, J
Yang, M 
Ko, F
Qin, L
Keywords: Anticancer activity
Anticancer drug resistance
Antimicrobial peptides
Electrostatic attraction
Hydrophobic interaction
Issue Date: 2015
Publisher: Binary Information Press
Source: Journal of fiber bioengineering and informatics, 2015, v. 8, no. 1, p. 25-36 How to cite?
Journal: Journal of fiber bioengineering and informatics 
Abstract: Antimicrobial Peptides (AMPs) were first known as a group of innate immune products that mainly targets on the invading pathogens among multiple species. The essential mechanisms of action of AMPs toward microbial cells have been reported as electrostatic attraction and hydrophobic interaction between AMPs (cationic AMPs) and microbial cell membranes. These effects also contribute to the potential mechanism of anticancer activities of AMPs as well. The membrane difference between cancer cells and normal cells are believed to play significant roles in AMPs orienting process. Membrane selective targeting properties make AMPs promising candidates for alternative approach to solve the problems from anticancer drug resistance.
ISSN: 1940-8676
DOI: 10.3993/jfbi03201503
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