Please use this identifier to cite or link to this item: http://hdl.handle.net/10397/16530
Title: Rapid screening of tetrodotoxin in urine and plasma of patients with puffer fish poisoning by HPLC with creatinine correction
Authors: Yu, CH
Yu, CF
Tam, S
Yu, PHF
Keywords: Chromatography
Clean-up
Fish and fish products
HPLC
Natural toxicants
Seafood
SPME
Toxicology
Issue Date: 2010
Publisher: Taylor & Francis Ltd
Source: Food additives and contaminants - part a chemistry, analysis, control, exposure and risk assessment, 2010, v. 27, no. 1, p. 89-96 How to cite?
Journal: Food Additives and Contaminants - Part A Chemistry, Analysis, Control, Exposure and Risk Assessment 
Abstract: A rapid and simple detection method for tetrodotoxin (TTX) in urine and plasma of patients with puffer fish poisoning was developed using commercially pre-packed solid-phase extraction (SPE) cartridges (C18 and weak cation exchange columns) and subsequent analyses by HPLC with UV detection. The detection limit of the standard TTX, TTX-spiked urine and plasma samples were all 10 ng/ml and the average TTX recovery in urine and plasma samples after SPE were 90.3 ± 4.0 and 87.1 ± 2.9%, respectively. It was noticed that the creatinine-adjusted urinary TTX levels obtained within the first 24 h of presentation apparently correlated much better with the severity of poisoning than the urinary TTX concentration without adjusting for variations in concomitant creatinine excretion.
URI: http://hdl.handle.net/10397/16530
DOI: 10.1080/02652030903207250
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