Please use this identifier to cite or link to this item: http://hdl.handle.net/10397/16404
Title: Treatment with nerve growth factor decreases expression of divalent metal transporter 1 and transferrin receptor in PC12 cells
Authors: Wang, J
Qian, ZM
Jiang, H
Xie, J
Ke, Y
Keywords: Divalent metal transporter 1 (DMT1)
Nerve growth factor (NGF)
Rat adrenergic neural tumour phaeochromocytoma cell line (PC12 cells)
Transferrin receptor (TfR)
Issue Date: 2005
Source: Neurochemistry international, 2005, v. 47, no. 7, p. 514-517 How to cite?
Journal: Neurochemistry International 
Abstract: Divalent metal transporter 1 (DMT1) and transferrin receptor (TfR) might play a key role in non-transferrin-bound iron (NTBI) and transferrin-bound iron (Tf-Fe) uptake by neuronal cells. Recent studies demonstrated that nerve growth factor (NGF)-treated PC12 cells (the neuronal phenotype) have higher NTBI as well as Tf-Fe uptake compared with untreated cells (the undifferentiated cells). We speculated the increased NTBI and Tf-Fe uptake induced by NGF treatment might be associated with the increased expression of DMT1 and TfR. In this study, we investigated the effect of NGF treatment on DMT1 and TfR expression in PC12 cells. Contrary to our expectation, treatment with NGF induced a significant decrease rather than increase in DMT1+IRE, DMT1-IRE and TfR expression in the cells. The data demonstrate that the increase in iron uptake is not associated with the DMT1 and TfR in NGF-treated PC12 cells. The RT-PCR findings of no change in DMT1 mRNA plus our data suggest that regulation of DMT1 expression by NGF might be at the post-transcriptional level.
URI: http://hdl.handle.net/10397/16404
ISSN: 0197-0186
DOI: 10.1016/j.neuint.2005.02.008
Appears in Collections:Journal/Magazine Article

Access
View full-text via PolyU eLinks SFX Query
Show full item record

SCOPUSTM   
Citations

4
Last Week
0
Last month
0
Citations as of Aug 20, 2017

WEB OF SCIENCETM
Citations

5
Last Week
0
Last month
0
Citations as of Aug 21, 2017

Page view(s)

38
Last Week
0
Last month
Checked on Aug 21, 2017

Google ScholarTM

Check

Altmetric



Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.