Please use this identifier to cite or link to this item: http://hdl.handle.net/10397/16357
Title: Gui-ling-gao (turtle jelly), a traditional Chinese functional food, exerts anti-inflammatory effects by inhibiting iNOS and pro-inflammatory cytokine expressions in splenocytes isolated from BALB/c mice
Authors: Zhang, H
Wu, MY
Guo, DJ
Wan, CW
Lau, CC
Chan, CO
Mok, DKW 
Chan, SW
Keywords: Anti-inflammatory
Lipopolysaccharide
Pro-inflammatory cytokines
Splenocytes
Turtle jelly
Issue Date: 2013
Publisher: Elsevier Science Bv
Source: Journal of functional foods, 2013, v. 5, no. 2, p. 625-632 How to cite?
Journal: Journal of Functional Foods 
Abstract: Gui-ling-gao (GLG), also known as turtle jelly, is a popular medicinal Chinese health/functional food prepared from several traditional Chinese medicinal herbs. The present study aimed at examining and explaining the anti-inflammatory properties of GLG by using lipopolysaccharide (LPS)-induced inflammation in splenocytes isolated from BALB/c mice. Additionally, the effects of GLG on mRNA and protein expressions of inducible nitric oxide synthase (iNOS) and pro-inflammatory cytokines in LPS-stimulated splenocyte proliferation were evaluated by real-time RT-PCR and Western blot assays. We demonstrated that GLG significantly inhibited LPS-induced splenocyte proliferation in a concentration-dependent manner. LPS-mediated up-regulations in the gene and protein expressions of iNOS, interleukin-1β (IL-1β) and tumour necrosis factor-alpha (TNF-α) were suppressed by GLG. These findings suggest for the first time that GLG exerts anti-inflammatory effects by inhibiting the expression of iNOS and pro-inflammatory cytokines such as IL-1β and TNF-α. The current study provides strong scientific evidence for the health-beneficial claim that consumption of GLG could help the body to modulate the immune system.
URI: http://hdl.handle.net/10397/16357
ISSN: 1756-4646
DOI: 10.1016/j.jff.2013.01.004
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