Please use this identifier to cite or link to this item: http://hdl.handle.net/10397/16201
Title: Synthesis of a precursor of bioactive pentapeptide OGP-(10-14) and the fragment of enkephalin catalyzed by MCM-22 immobilized or free proteases in organic solvents
Authors: Liu, P
Ye, YH
Tian, GL
Lee, KS
Wong, MS 
Lo, WH 
Keywords: Enzymatic peptide synthesis
Immobilized enzyme
MCM-22
OGP-(10-14)
Organic solvents
Issue Date: 2002
Publisher: Georg Thieme Verlag
Source: Synthesis, 2002, v. , no. 6, p. 726-732 How to cite?
Journal: Synthesis 
Abstract: Full enzymatic synthesis of a precursor of osteogenic growth peptide fragment (10-14), Z-Tyr-Gly-Phe-Gly-Gly-OEt, was accomplished using immobilized proteases on molecular sieve MCM-22 by adsorption as catalyst via 3+2 synthetic route for the first rime. The reuse time of immobilized enzyme was dependent on concrete reaction system. Compared with free enzyme, the reaction rate catalyzed by immobilized enzyme was remarkably enhanced and its synthetic yield was also increased in most cases. The effects of water content and the added amount of Et 3N on synthesis of fragments of bioactive peptides including OGP-(10-14) and enkephalin by immobilized enzymes were different from free enzyme.
URI: http://hdl.handle.net/10397/16201
ISSN: 0039-7881
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