Please use this identifier to cite or link to this item: http://hdl.handle.net/10397/15845
Title: A surface-charge study on cellular-uptake behavior of F3-peptide-conjugated iron oxide nanoparticles
Authors: Zhang, Y
Yang, M 
Park, JH
Singelyn, J
Ma, H
Sailor, MJ
Ruoslahti, E
Ozkan, M
Ozkan, C
Keywords: Cellular uptake
F3 peptide
Iron oxide nanoparticles
Zeta potential
Issue Date: 2009
Publisher: Wiley-VCH
Source: Small, 2009, v. 5, no. 17, p. 1990-1996 How to cite?
Journal: Small 
Abstract: Surface-charge measurements of mammalian cells in terms of Zeta potential are demonstrated as a useful biological characteristic in identifying cellular interactions with specific nanomaterials. A theoretical model of the changes in Zeta potential of cells after incubation with nanoparticles is established to predict the possible patterns of Zeta-potential change to reveal the binding and internalization effects. The experimental results show a distinct pattern of Zeta-potential change that allows the discrimination of human normal breast epithelial cells (MCF-10A) from human cancer breast epithelial cells (MCF-7) when the cells are incubated with dextran coated iron oxide nanoparticles that contain tumor-homing F3 peptides, where the tumor-homing F3 peptide specifically bound to nucleolin receptors that are overexpressed in cancer breast cells.
URI: http://hdl.handle.net/10397/15845
ISSN: 1613-6810
EISSN: 1613-6829
DOI: 10.1002/smll.200900520
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