Please use this identifier to cite or link to this item: http://hdl.handle.net/10397/15247
Title: Semi-synthesis and proteasome inhibition of D-ring deoxy analogs of (-)-epigallocatechin gallate (EGCG), the active ingredient of green tea extract
Authors: Huo, C
Shi, G
Lam, WH
Chen, D
Cui, QC
Dou, QP
Chan, TH
Issue Date: 2008
Source: Canadian journal of chemistry, 2008, v. 86, no. 6, p. 495-502
Abstract: A semi-synthetic route to the D-ring analogs of (-)-epigallocatechin gallate (EGCG) from the relatively abundant (-)-epigallocatechin (EGC), isolated from, green tea leaves, is described. A natural product (13), found in Cistus salvifolius, its acetate (14) and analog (17) were synthesized by this method. Their inhibitory activities against proteasomes were investigated.
Keywords: (-)-epigallocatechin (EGC)
(-)-epigallocatechin gallate (EGCG)
Green tea
Proteasome inhibition
Publisher: National Research Council Canada
Journal: Canadian journal of chemistry 
ISSN: 0008-4042
EISSN: 1480-3291
DOI: 10.1139/V07-141
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