Please use this identifier to cite or link to this item: http://hdl.handle.net/10397/15051
Title: Synthesis and cytotoxicity of 9-substituted benzo[de]chromene-7,8-dione and 5-benzyl-9-substituted benzo[de]chromene-7,8-dione
Authors: Huang, SL
Luo, Y
Huang, ZS
Wang, XY
Bu, XZ
Liu, PQ
Ma, L
Xie, BF
Liu, ZC
Li, YM
Chan, ASC
Gu, LQ
Keywords: Antitumor
Mansonone F
Oxidation debenzyl rearrangement
Selective hydrolization
Issue Date: 2006
Publisher: Taylor & Francis Inc
Source: Synthetic communications, 2006, v. 36, no. 18, p. 2667-2684 How to cite?
Journal: Synthetic Communications 
Abstract: New Mansonone analogues of 9-substitued benzo[de]chromene-7,8-dione 5b-e and 5-benzyl-9-substitued benzo[de]chromene-7,8-dione 6a-e were prepared through a modified route. The first step involved a bulky base t-butylamine mediated regioselective deacetylation of 2-substituted-1,4-naphth-diyl diacetate, resulting in obtaining of monoacetate 4-acetate 2 in high yield. The mechanism of cyclization, debenzylation, and oxidation for the formation of 5a-e and 6a-e were discussed. The cytotoxicity of the prepared compounds 5 and 6 were comparable with naturally occurring Mansonone F.
URI: http://hdl.handle.net/10397/15051
ISSN: 0039-7911
DOI: 10.1080/00397910600764683
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