Please use this identifier to cite or link to this item: http://hdl.handle.net/10397/15021
Title: Iridium-catalyzed cascade decarbonylation/highly enantioselective Pauson-Khand-type cyclization reactions
Authors: Kwong, FY 
Lee, HW
Lam, WH
Qiu, L
Chan, ASC
Issue Date: 2006
Publisher: Pergamon Press
Source: Tetrahedron : asymmetry, 2006, v. 17, no. 8, p. 1238-1252 How to cite?
Journal: Tetrahedron : asymmetry 
Abstract: An easily accessible chiral iridium-BINAP complex can effect the cooperative processes of decarbonylation of an aldehyde and cascaded enantioselective Pauson-Khand-type reaction. A survey of ligands revealed that atropisomeric aryl-diphosphine ligands were superior to chiral alkyl-diphosphines in this dual catalysis. Applying the reaction conditions of [IrCl(COD)](2)/(S)-BINAP complex with nonylaldehyde as a CO surrogate at 100 degrees C in anhydrous dioxane solvent, various 1,6-enynes were transformed to the corresponding optically active bicyclic cyclopentenones with excellent enantioselectivities (up to 98% ee).
URI: http://hdl.handle.net/10397/15021
ISSN: 0957-4166
EISSN: 1362-511X
DOI: 10.1016/j.tetasy.2006.03.036
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