Please use this identifier to cite or link to this item: http://hdl.handle.net/10397/14924
Title: Iron misregulation in the brain : a primary cause of neurodegenerative disorders
Authors: Ke, Y
Qian, ZM
Issue Date: 2003
Publisher: Lancet Ltd
Source: Lancet neurology, 2003, v. 2, no. 4, p. 246-253 How to cite?
Journal: Lancet Neurology 
Abstract: High iron concentrations in the brains of patients and the discovery of mutations in the genes associated with iron metabolism in the brain suggest that iron misregulation in the brain plays a part in neuronal death in some neurodegenerative disorders, such as Alzheimer's, Parkinson's, and Huntington's diseases and Hallervorden-Spatz syndrome. Iron misregulation in the brain may have genetic and non-genetic causes. The disrupted expression or function of proteins involved in iron metabolism increases the concentration of iron in the brain. Disturbances can happen at any of several stages in iron metabolism (including uptake and release, storage, intracellular metabolism, and regulation). Increased brain iron triggers a cascade of deleterious events that lead to neurodegeneration. An understanding of the process of iron reglation in the brain, the proteins important in this process, and the effects of iron misregulation could help to treat or prevent neurodegenerative disrders.
URI: http://hdl.handle.net/10397/14924
ISSN: 1474-4422
DOI: 10.1016/S1474-4422(03)00353-3
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