Please use this identifier to cite or link to this item: http://hdl.handle.net/10397/14894
Title: Antioxidative iridoid glycosides from the sky flower (Duranta repens Linn)
Authors: Ijaz, F
Haq, AU
Ahmad, I
Ahmad, N
Hussain, J
Chen, S
Keywords: antioxidant
Duranta repens
iridoid glycosides
Verbenaceae
Issue Date: 2011
Publisher: Informa Healthcare
Source: Journal of enzyme inhibition and medicinal chemistry, 2011, v. 26, no. 1, p. 88-92 How to cite?
Journal: Journal of Enzyme Inhibition and Medicinal Chemistry 
Abstract: Phytochemical investigations were performed on the EtOAc-soluble fraction of the whole plant of the sky flower (Duranta repens) which led to the isolation of the iridoid glycosides 1-6. Their structures were elucidated by both 1D and 2D NMR spectroscopic analysis. All the compounds showed potent antioxidative scavenging activity in four different tests, with half maximal inhibitory concentration (IC 50) values in the range 0.481-0.719 mM against DPPH radicals, 4.07-17.21 μ M for the hydroxyl radical ( •OH) inhibitory activity test, 43.3-97.37 μ M in the total reactive oxygen species (ROS) inhibitory activity test, and 3.39-18.94 μ M in the peroxynitrite (ONOO -) scavenging activity test. Duranterectoside A (1) displayed the strongest scavenging potential with IC50 values of (0.481 ± 0.06 mM, 4.07 ± 0.03, 43.30 ± 0.05, 3.39 ± 0.02 μ M) for the DPPH radicals, •OH inhibitory activity test, total ROS inhibitory activity test and the ONOO - scavenging activity test, respectively.
URI: http://hdl.handle.net/10397/14894
DOI: 10.3109/14756361003724778
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