Please use this identifier to cite or link to this item: http://hdl.handle.net/10397/14858
Title: Folic acid consumption reduces resistin level and restores blunted acetylcholine-induced aortic relaxation in obese/diabetic mice
Authors: Seto, SW
Lam, TY
Or, PMY
Lee, WYW
Au, ALS
Poon, CCW
Li, RWS
Chan, SW
Yeung, JHK
Leung, GPH
Lee, SMY
Ngai, SM
Kwan, YW
Keywords: +db/+db mice
Acetylcholine
ENOS
Folic acid
PTEN
Relaxation
Issue Date: 2010
Publisher: Elsevier Science Inc
Source: Journal of nutritional biochemistry, 2010, v. 21, no. 9, p. 872-880 How to cite?
Journal: Journal of Nutritional Biochemistry 
Abstract: Folic acid supplementation provides beneficial effects on endothelial functions in patients with hyperhomocysteinemia. However, its effects on vascular functions under diabetic conditions are largely unknown. Therefore, the effect(s) of folic acid (5.7 and 71 ?gg/kg/day for 4 weeks) on aortic relaxation was investigated using obese/diabetic (+db/+db) mice and lean littermate (+db/+m) mice. Acetylcholine-induced relaxation in +db/+db mice was less than that observed in +db/+m mice. The reduced relaxation in +db/+db mice was restored by consumption of 71 ?gg/kg folic acid. Acetylcholine-induced relaxation (with and without folic acid treatment) was sensitive to N G-nitro-l-arginine methyl ester, 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one, geldanamycin and triciribine. In addition, acetylcholine-induced relaxation was attenuated by resistin. The plasma level of resistin in +db/+db mice was sevenfold higher than that measured in +db/+m mice, and the elevated plasma level of resistin in +db/+db mice was reduced by 25% after treatment with 71 ?gg/kg folic acid. Foli
URI: http://hdl.handle.net/10397/14858
ISSN: 0955-2863
DOI: 10.1016/j.jnutbio.2009.06.015
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