Please use this identifier to cite or link to this item: http://hdl.handle.net/10397/14788
Title: Molecular weight-dependent anticoagulation activity of sulfated cellulose derivatives
Authors: Wang, ZM
Xiao, KJ
Li, L
Wu, JY 
Keywords: Acidic degradation
Anticoagulation
Ionic liquid
Molecular weight
Sulfated cellulose derivatives
Issue Date: 2010
Publisher: Springer
Source: Cellulose, 2010, v. 17, no. 5, p. 953-961 How to cite?
Journal: Cellulose 
Abstract: This work is to examine the molecular weight (MW)-anticoagulation activity relationship of sulfated cellulose derivatives (cellulose sulfates, CS). The initial CS with a degree of substitution (1.59) was prepared by homogeneous sulfation of microcrystalline cellulose in an ionic liquid [C4mim]Cl. It was then hydrolyzed in a dilute acidic solution and separated into four MW fractions of 59, 23, 10 × 103 g/mol and below 2.7 × 103 g/mol. The anticoagulation activities based on in vitro assays of coagulation time and coagulation factors in human plasma showed a positive correlation with the MW of CS, while the activity assay of clotting time in rats exhibited a negative correlation with the MW 10-59 × 103 g/mol, and the fraction with a MW <2.7 × 103 g/mol exhibited a more moderate and durable activity. The results indicate that MW is a major factor on the anticoagulant properties of CS derivatives and higher MW range is favorable for in vitro, and lower MW suitable for in vivo applications.
URI: http://hdl.handle.net/10397/14788
DOI: 10.1007/s10570-010-9441-7
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