Please use this identifier to cite or link to this item: http://hdl.handle.net/10397/14765
Title: Effect of composition of poly(3-hydroxybutyrate-co-3-hydroxyhexanoate) on growth of fibroblast and osteoblast
Authors: Wang, YW
Yang, F
Wu, Q
Cheng, YC
Yu, PHF
Chen, J
Chen, GQ
Keywords: Biocompatibility
Fibroblast
Osteoblast
PHB
PHBHHx
Poly (3-hydroxybutyrate-co-3-hydroxyhexanoate)
Issue Date: 2005
Source: Biomaterials, 2005, v. 26, no. 7, p. 755-761 How to cite?
Journal: Biomaterials 
Abstract: Films made of poly (3-hydroxybutyrate) (PHB), poly(3-hydroxybutyrate- co-3-hydroxyhexanoate) (PHBHHx) consisting of 5%, 12% and 20% hydroxyhexanoate (HHx), respectively, were evaluated for biomedical application in comparison with poly (L-Lactide) (PLA). With the increase of HHx content in PHBHHx, the polymer surface properties changed accordingly. P(HB-co-20%-HHx) had the smoothest surface while PHB surface was most hydrophilic among the evaluated PHB and all the PHBHHx. All PHBHHx also showed strong protein affinity and biocompatibility. It was found that fibroblast and osteoblast had different responses to these polymers: fibroblast cells favored P(HB-co-20%-HHx), yet osteoblast cells preferred P(HB-co-12%-HHx). PHB and all PHBHHx appeared to have better biocompatibility for fibroblast and osteoblast compared with PLA. Polymers possessing diferent surface properties may help meet different cellular requirements. Combined with their good mechanical properties for elongation and adjustable biocompatibility, PHBHHx may meet the needs of growth requirements of different tissues and cells.
URI: http://hdl.handle.net/10397/14765
ISSN: 0142-9612
DOI: 10.1016/j.biomaterials.2004.03.023
Appears in Collections:Journal/Magazine Article

Access
View full-text via PolyU eLinks SFX Query
Show full item record

SCOPUSTM   
Citations

83
Last Week
0
Last month
0
Citations as of Aug 12, 2017

WEB OF SCIENCETM
Citations

75
Last Week
0
Last month
1
Citations as of Aug 13, 2017

Page view(s)

37
Last Week
2
Last month
Checked on Aug 13, 2017

Google ScholarTM

Check

Altmetric



Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.